Haemoglobin Volga, β27, (B9) Ala → Asp, a new highly unstable haemoglobin with a suppressed charge

The clinical features of unstable haemoglobin disease.

Unstable haemoglobin Köln disease in members of a Malay family.

A group of unstable haemoglobins associated with congenital nonspherocytic haemolytic anaemia has recently been recognized. They are characterized by the instability of the haemoglobin solutions and by being heat labile. Contrary to most known abnormal haemoglobins reported to date, their presence in the blood is not always easy to demonstrate by electrophoretic methods. In the red blood cells ...

New 13-Chain Variant of Haemoglobin A Found in Combination with Haemoglobin S

During a routine study of the parents of a 3month-old Jamaican child with the sickle-cell trait the father was found to have a haemoglobin electrophoretic pattern identical to that of homozygous sickle-cell disease. Because he was perfectly well and had no haematological abnormalities detailed studies of his haemoglobin constitution were undertaken. These indicate that he is heterozygous for bo...

Haemoglobin Osu - Christiansborg : A New - chain Variant of Haemoglobin A ( , 352 ( D 3 ) Aspartic Acid - - Asparagine ) in Combination with Haemoglobin S

A 63-year-old man, a member of the Ga tribe from the Osu-Christiansborg area in Accra was examined for hypertension. On incubation with 2% sodium metabisulphate his red cells readily sickle. Only two haemoglobin bands were demonstrated by paper electrophoresis at pH 8-9 (Cradock-Watson, Fenton, and Lehmann, 1959) and starch gel electrophoresis atpH 8-6 (Poulik, 1957), a minor one corresponding ...

HemoCue haemoglobin systems--a clarification.

The preferred method to verify the accuracy of a haemoglobinometer is the International Committee for Standardization in Haematology (ICSH) reference measurement of haemoglobin as haemiglobincyanide in whole blood, using a spectrophotometer which has been calibrated directly by the WHO/ICSH primary international reference standard or by means of a commercial standard that has been manufactured ...